Ohnuki Y, Kawai N, tanaka E, Langenbach GE, Tanne K, Saeki Y : Effects of increased occlusal vertical dimension on daily activity and myosin heavy chain composition in rat jaw muscle.

Arch Oral Biol 54, 783-789, 2009.


Okumura S, Suzuki S, Ishikawa Y : New aspects for the treatment of cardiac diseases based on diversity of functional controls on cardiac muscles: effects of targeted disruption of the type 5 adenylyl cyclkase gene.

J Phramacol Sci, 109; 354-359, 2009.


Sato M, Jiao Q, Honda T, Kurotani R, Toyota E, Okumura S, Takeya T, Minamisawa S, Lanier SM, Ishikawa Y: Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of Gbg and connexin 43 (CX43).

J Biol Chem, 284, 31431-31440, 2009.


Okumura S, Tsunematsu T, Bai Y, Jiao Q, Ono S, Suzuki S, Kurotani R, Sato M, Umemura S, Minamisawa S, Ishikawa Y: Type 5 adenylyl cyclase plays a major role in stabilizing heart rate in response to microgravity induced by parabolic flight.

J Apply Physiol 105, 173-179, 2008.


Ohnuki Y, Saeki Y: Jaw-opening muscle contracts more economically than jaw-closing muscle in rats.

Arch Oral Biol 53, 193-198, 2008.


Okumura S, Vatner DE, Kurotani R, Bai Y, Gao S, Yuan Z, Iwatsubo K, Ulucan C, Kawabe, JI,Ghosh K, Vatner SF, Ishikawa Y: Disruption of Type 5 Adenylyl CyclaseEnhances Desentization of cyclic Adenosine Monophosphate Signal and increases Akt signal with chronic catecholamine stress.

Circulation 116, 1776-1783, 2007


Ulucan C, Wang X, Baljinnyam E, Bai YZ, Okumura S, Sato M, Minamisawa S, Horotani S, Ishikawa Y. Depelopmental changes in gene expression of Epac and itsupregulation in myocardial hypertrophy.

Am J Physiol Heart Circ Physiol. 293, H1662-H1672, 2007.


Iwatsubo K, Suzuki S, Li C, Tsunematsu T, Nakamura F, Okumura S, Sato M, Minamisawa S, Toya Y, Umemura S, Ishikawa Y.

Dopamine induces apoptosis in young but not in neonatal neurons via Ca2+-dependent signal

Am J Physiol Cell Physiol, 293, C1498-C1508, 2007.


Akiyama N, Ohnuki Y, Kunioka Y, Saeki Y, Yamada T: Transverse stiffness of myofibrils of skeletal and cardiac muscles studied by atomic force microscopy.

J Physiol Sci 56, 145-151, 2006.   日本生理学会 JPS優秀論文賞(入澤賞)受賞論文(2007年3月)


Arai C, Ohnuki Y, Umeki D, Hirashita A, Saeki Y: Effects of clenbuterol and cyclosporine A on the myosin heavy chain mRNA level and the muscle mass in rat masseter.

J Physiol Sci 56, 205-209, 2006.


Arai C, Ohnuki Y, Umeki D, Saeki Y: Effects of bite-opening and cyclosporine A on the mRNA levels of myosin heavy chain and the muscle mass in rat masseter.

Jpn J Physiol 55, 173-179, 2005.


Nishimura S, Yamashita H, Katoh M, Yamada KP, Sunagawa K, Saeki Y, Ohnuki Y, Nagai R, Sugiura S: Contractile dysfunction of cardiomyopathic hamster myocytes is pronounced under high load condition.

J Mol Cell Cardiol 39, 231-239, 2005.


Kawabe J, Okumura S, Lee MC, Sadoshima J, Ishikawa Y: Translocation of caveolin regulates stretch-induced activity in vascular smooth muscle cells.

Am J Physiol Heart Circ Physiol. 286, H1845-H1852, 2004.


Okumura S, Takagi G, Kawabe J, Yang G, Lee M-C, Hong C,Liu J, Vatner DE, Sadoshima J, Vatner SF, Ishikawa Y: Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload.

Proc Natl Acad Sci USA 100, 9986-9990, 2003.


Okumura S, Kawabe J, Yatani A, Takagi G, Lee M-C, Hong C, LiuJ, Takagi I, Sadoshima J, Vatner DE, Vatner SF, Ishikawa Y: Type 5 adenylyl cyclase disruption alters not only sympathetic but also paras y mpathetic and calcium-mediated cardiac regulation.

Circ Res 93, 364-371, 2003.

FASEB Experimental Biology Meeting meeting Young Investigator Award 受賞論文 (2002年4月:New Orleans, LA)


Iwamoto T*, Okumura S*, Iwatsubo K, Kawabe J, Ohtsu K, Sakai I, Hashimoto Y,Izumitani A, Sango K, Ajiki K, Toya Y, Umemura S, Goshima Y, Arai N, Vatner SF, Ishikawa Y : Motor dysfunction in type 5 adenylyl cyclase-null mice.

J Biol Chem 278, 16936-16940, 2003.

(* Both authors contributed equally to this work).