Kiyomoto K, Matsuo I, Suita K, Ohnuki Y, Ishikawa M, Ito A, Mototani Y, Tsunoda M, Morii A, Nariyama M, Hayakawa Y, Amitani Y, Gomi K, Okumura S*

Oral angiotensin-converting enzyme inhibitor captopril protects the heart from Porphyromonas gingivalis LPS-induced cardiac dysfunction in mice

PLoS One 18, e0292624, 2023


Ito A, Ohnuki Y, Suita K, Matsuo I, Ishikawa M, Mitsubayashi T, Mototani Y, Kiyomoto K, Tsunoda M, Morii A, Nariyama M, Hayakawa Y, Tomonari H, Okumura S* 

Effects of the angiotensin-converting enzyme inhibitor captopril in occlusal-disharmony-induced cardiac dysfunction in mice

Sci Rep 13, 199127, 2023


Tsunoda M, Matsuo I, Ohnuki Y, Suita K, Ishikawa M, Ito A, Mototani Y, Kiyomoto K, Morii A, Nariyama M, Hayakawa Y, Gomi K, Okumura S*: Vidarabine, an anti-herpes agent, improves Porphyromonas gingivalis lipopolysaccharide-induced cardiac dysfunction in mice

J Physiol Sci 73, 18, 2023


Matsuo I, Kawamura N, Ohnuki Y, Suita K, Ishikawa M, Matsubara T, Mototani Y, Ito A, Hayakawa Y, Nariyama M, Morii A, Kiyomoto K, Tsunoda M, Gomi K, Okumura S* : Role of TLR4 signaling on Porohylomonas gingivalis LPS-induced cardiac dysfunction in mice

PLoS One 17, e0258823, 2022


Hayakawa Y, Suita K, Ohnuki Y, Mototani Y, Ishikawa M, Ito A, Nariyama M, Morii A, Kiyomoto K, Tsunoda M, Matsuo I, Kawahara H,    Okumura S*:Vidarabine, an anti-herpes agent, prevents occlusal-disharmony-induced cardiac dysfunction in mice

J Physiol Sci 72, 2, 2022


Matsuo I, Ohnuki Y, Suita K, Ishikawa M, Mototani Y, Ito A, Hayakawa Y, Nariyama M, Morii A, Kiyomoto K, Tsunoda M, Gomi K, Okumura S* Effects of chronic Porphylomonas gingivalis lipopolysaccharide infusion on cardiac function in mice

J Oral Biosci 63, 394-400, 2021 


Shiozawa K, Mototani Y, Suita K, Ito A, Matsuo I, Hayakawa Y, Kiyomoto K, Tsunoda M, Nariyama M, Ohnuki Y, Okumura S*:Gender differences in eating behavior and masticatory performance: An analysis of the Three-Factor-Eating Questionnaire and its association with the body mass index in healthy subjects

J Oral Biosci 62, 357-362, 2020


Suita K, Yagisawa Y, Ohnuki Y, Umeki D, Nariyama M, Ito A, Hayakawa Y, Matsuo I, Mototani Y, Saeki Y, Okumura S*:Effects of occlusal disharmony on susceptibility to atrial fibrillation in mice

Sci Rep 10, 13765, 2020


Yagisawa Y, Suita K, Ohnuki Y, Ishikawa M, Mototani Y, Ito A, Matsuo I, Hayakawa Y, Nariyama M, Umeki D, Saeki Y, Amitani Y, Nakamura Y, Tomonari H, Okumura S*: Effects of occlusal disharmony on cardiac fibrosis, myocyte apoptosis and myocyte DNA damage in mice

PLoS One 15, e0236547, 2020


八木澤由佳、吹田憲治、大貫芳樹、伊藤愛子、梅木大輔、友成  博、奥村 敏*: 実験的咬合異常がマウスの心機能に及ぼす影響について

循環制御 41(9), 38-45, 2020


Kanzaki H, Wada S, Kumazawa M, Yamada Y, Sudo T, Ozawa E, Seko T, Akaike S, Murakami M, Oikawa T, Okumura S, Nakamura Y, Tomonari H: Mandibular prognathism attenuates brain blood flow induced by chewing

Sci Rep 9, 19104, 2019


Ito A, Ohnuki Y, Suita K, Ishikawa M, Mototani Y, Shiozawa K, Kawamura N, Yagisawa Y, Nariyama M, Umeki D, Nakamura Y, Okumura S*: Role of  β-adrenergic signaling in masseter muscle

PLoS One 14, e0215539, 2019


Kawamura N, Ohnuki Y, Matsuo I, Suita K, Ishikawa M, Mototani Y, Shiozawa K, Ito A, Yagisawa Y, Hayakawa Y, Nariyama M, Ujiie Y, Gomi K, Okumura S*: Effects of chronic Porphylomonas gingivalis lipopolysaccharide infusion on skeletal muscle in mice

J Physiol Sci 69, 503-511, 2019


Prajapati R, Fujita T, Suita K, Nakamura T, Cai W, Hidaka Y, Umemura M, Yokoyama U, Knollmann B, Okumura S, Ishikawa Y: The usefulness of exchanged protein directly activated by cAMP (Epac) 1-inhibiting therapy for prevention of atrial and ventricular arrhythmia in mice      

Circ J 83, 293-303, 2019


Shiozawa K, Mototani Y, Suita K, Ito A, Kawamura N, Yagisawa Y, Matsuo I, Hayakawa Y, Nariyama M, Umeki D, Saeki Y, Ohnuki Y, Okumura S*: Relationship between bite size per mouthful and dental arch size in healthy subjects

J Physiol Sci 69, 159-163, 2019


石川義弘、吹田憲治、Prajapati R、藤田孝之、奥村 敏:心房細動の新規治療標的

心電図 39(2), 155-159, 2019


Mototani Y, Okamura T, Goto M, Shimizu Y, Yanobu-Takanashi R, Ito A, Kawamura N, Yagisawa Y, Umeki D, Nariyama M, Suita K, Shiozawa K, Sahara Y, Kozasa T, Saeki Y, Okumura S*: Role of G-protein-regulated inducer of neurite outgrowth 3 (GRIN3) in β-arrestin 2-Akt signaling and dopaminergic behaviors

Pflugers Arch 470, 937-946, 2018


Suita K, Fujita T, Cai W, Jin H, Prajapati R, Hidaka Y, Umemura M, Yokoyama U, Sato M, Okumura S, Ishikawa Y: Vidarabine, an-anti-herpes virus agent prevents catecholamine-induced arrhythmia without adverse effect on heart function in mice

Pfluger Arch 470, 923-935, 2018


Jin H, Fujita T, Jin M, Kurotani R, Hidaka Y, Cai W, Suita K, Prajapati R, Liang C, Ohnuki Y, Mototani Y, Umemura M, Yokoyama U, Sato M, Okumura S*, Ishikawa Y: Epac activation inhibits IL-6-induced cardiac dysfunction  日本生理学会 第9回 入沢宏 彩記念 心臓循環論文賞

J Physiol Sci 68, 77-87, 2018


Umemura M, Kim J-H, Aoyama H, Hoshino Y, Fukumura H, Nakakaji R, Sato I, Ohtake M, Akimoto T, Narikawa M, Tanaka R, Fujita T, Yokoyama U, Taguri M, Okumura S, Sato M, Eguchi H, Ishikawa Y: The iron chelating agent, deferoxamine detoxies (Salen)-induced cytotoxity

J Pharmacol Sci 134, 203-210, 2017


Jin H, Fujita T, Jin M, Kurotani R, Namekata I, Hamaguchi S, Hidaka Y, Cai W, Suita K, Ohnuki Y, Mototani Y, Shiozawa K, Prajapati R, Liang C, Umemura M, Yokoyama U, Sato M, Tanaka H, Okumura S*, Ishikawa Y: Cardiac overexpression of Epac1 in transgenic mice rescues lipopolysaccharide-induced cardiac dysfunction and inhibits Jak-STAT pathway.

J Mol Cell Cardiol 108, 170-180, 2017


Fujita T, Umemura M, Yokoyama U, Okumura S, Ishikawa Y: The role of Epac in the heart.

Cell Mol Life Sci 74, 591-601, 2017.


Ohnuki Y, Umeki D, Mototani Y, Shiozawa K, Ito A, Kawamura N, Jin H, Cai W, Suita K, Saeki Y, Fujita T, Ishikawa Y, Okumura S*: Role of phosphodiesterase 4 expression in the Epac1 signal-dependent skeletal muscle hypertrophic action of clenbuterol.

Physiol Rep 4, e12791, 2016.


Cai W, Fujita T, Hidaka Y, Jin H, Suita K, Ling C, Parajapati R, Umemura M, Yokoyama U, Sato M, Okumura S*, Ishikawa Y: Disruption of Epac1 protects the heart from adenylyl cyclase type5-mediated cardiac dysfunction.

Biochem Biophys Res Commun , 457, 1-7, 2016.


Sato I, Umemura M, Mitsudo K, Fukumura H, Kim J-H, Hoshino Y, Nakashima H, Kioi M, Nakakaji R, Sato M, Fujita T, Yokoyama U, Okumura S, Oshiro H, Eguchi H, Tohnai I, Ishikawa Y: Simultaneous hyperthermia-chemotherapy with controlled drug delivery using single-drug nanoparticles.

Sci Rep 6, 24629, 2016.


Shiozawa K, Ohnuki Y, Mototani Y, Umeki D, Ito A, Saeki Y, Hanada N, Okumura S*:Effects of food diameter on bite size per mouthful and chewing behavior.

J Physiol Sci 66, 93-98, 2016


Kato Y, Yokoyama U, Yanai C, Ishige R, Kurotaki D, Umemura M, Fujita T, Kubota T, Okumura S, Sata M, Tamura T, Ishikawa Y: Epac1 deficiency attenuated vascular cell migration and neointimal formation.

Arterioscler Thromb Vascular Biol 35, 2617-2625, 2015.


Suita K, Fujita T, Hasegawa N, Cai W, Jin H, Hidaka Y, Prajapati R, Umemura M, Yokoyama U, Sato M, Okumura S, Ishikawa Y: Norepinephrine-induced adrenergic activation strikingly increased the atrial fibrillation through β1- and α1-adrenergic receptor –mediated signaling in mice.

PLoS One 10, e0133604, 2015.


Nariyama M, Mori M, Shimazaki E, Ando H, Ohnuki Y, Abo T, Yamane A, Asada Y: Functions of miR-1 and miR-133a during the postnatal development of masseter and gastrocnemius muscles.

Mol Cell Biochem 407 (1-2), 17-27, 2015


Umeki D, Ohnuki Y, Mototani Y, Shiozawa K, Suita K, Fujita T, Nakamura Y, Saeki Y, Okumura S*: Protective effects of clenbuterol against dexamethasone-induced masseter muscle atrophy and myosin heavy chain transition.

PLoS One 10, e02128263, 2015


Tsunematsu T, Okumura S*, Mototani Y, Ohnuki Y, Jin H, Cai W, Suita K, Sato I, Umemura M, Yokoyama U, Sato M, Fujita T, Ishikawa Y: Coupling of β1-adrenergic receptor to type 5 adenylyl cyclase and its physiological relevance in cardiac myocytes.

Biochem Biophys Res Commun 458, 531-535, 2015.


Kamide T, Okumura S*, Ghosh S, Shinoda Y, Motatini Y, Ohnuki Y, Jin H, Cai W, Suita K, Sato I, Umemura M, Fujita T, Yokoyama U, Sato M, Furutani K, Kitano H, Ishikawa Y: Oscillation of cAMP and Ca2+ in cardiac myocytes: a systems biology approach.

J Physiol Sci, 65, 195-200, 2015.


Okumura S*, Fujita T, Cai W, Jin M, Namekata I, Mototani Y, Jin H, Ohnuki Y, Tsuneoka Y, Kurotani R, Suita K, Kawakami Y, Hamaguchi S, Abe T, Kiyonari H, Tsunematsu T, Bai Y, Suzuki S, Hidaka Y, Umemera M, Ichikawa Y, Yokoyama U, Sato M, Ishikawa F, Izumi-Nakaseko H, Adachi-Akahane S, Tanaka H, Ishikawa Y : Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses.

J Clin Invest 124, 2785-2801, 2014.


Ohnuki Y, Umeki D, Mototani Y, Jin H, Cai W, Shiozawa K, Suita K, Saeki Y, Fujita T, Ishikawa Y, Okumura S* : Role of cyclic AMP sensor Epac1 in masseter muscle hypertrophy and myosin heavy chain transition induced by b2-adrenoceptor stimulation.

J Physiol 592, 5461-5475, 2014.


Hachijo N, Kawai N, Mori H, Sano R, Ohnuki Y, Okumura S, Langenbach GE, Tanaka R : Effects of the masticatory demand on the rat mandibular development.

J Oral Rehabil 41, 581-587, 2014.


Aoki R, Yokoyama U, Ichikawa Y, Taguri M, Kumagaya S, Ishiwata R, Yanai C, Fujita S, Umemura M, Fujita T, Okumura S, Sato M, Minamisawa S, Asou T, Masuda M, Iwasaki S, Nishimaki S, Seki K, Yokota S, Ishikawa Y : Decreased serum osmolarity promotes ductus arteriosus constriction.

Cardiovasc Res 104, 326-336, 2014.


Sato M, Hiraoka M, Suzuki M, Sakima M, Mamun AA, Yamane Y, Fujita T, Yokoyama U, Okumura S, Ishikawa Y : Protection of cardiomyocytes from the hypoxia-mediated injury by a peptide targeting the activator of G-protein signaling 8

PLoS One 14, e91980, 2014.


Sato I, Umemura M, Mitsudo K, Kioi M, Nakashima H, Iwai T, Feng X, Oda K, Miyajima A, Makino A, Iwai M, Fujita T, Yokoyama U, Okumura S, Sato M, Eguchi H, Tohnai I, Iahikawa Y : Hyperthermia generated with ferucarbotran (Risovist) in an altering magnetic field enhances cisplatin-induced apoptosis of cultured human oral cancer.

J Physiol Sci 64, 177-183, 2014.


Sugi H, Chaen S, Kobayashi T, Abe T, Kimura K, Saeki Y, Ohnuki Y, Miyakawa T, Tanokura M, Sugiura S: Definite differences between in vitro actin-myosin sliding and muscle contraction as revealed using antibodies to myosin head.

PLoS One 11, e93272, 2014.


Ohnuki Y, Yamada T, Mototani Y, Umeki D, Shiozawa K, Fujita T, Saeki Y, Okumura S* : Effect of protein kinase A on the phosphorylation status and transverse stiffness of cardiac myofibrils.

J Pharamacol Sci 123, 279-283, 2013.


Ohnuki Y, Umeki D, Cai W, Kawai N, Mototani Y, Shiozawa K, Jin HL, Fujita T, Tanaka E, Saeki Y, Okumura S* : Role of masseter muscle b2-adrenergic signaling in regulation of muscle activity, myosin heavy chain transition, and hypertrophy.

J Pharmacol Sci 123, 36-46, 2013.


Umeki D, Ohnuki Y, Mototani Y, Shiozawa K, Fujita T, Nakamura Y, Saeki Y, Okumura S* : Effects of chronic Akt/mTOR inhibition by rapamycin on mechanical overload-induced hypertrophy and myosin heavy chain transition in masseter muscle.

J Pharmacol Sci 122, 278-288, 2013.


Sugi H, Abe T, Kobayashi T, Chaen S, Ohnuki Y, Saeki Y, Sugiura S : Enhancement of force generated by individual myosin heads in skeletal rabbit psoas muscle fibers at low ionic strength.

PLoS One 8, e63658, 2013.


Nakamura S, Kawai N, Ohnuki Y, Saeki Y, Korfage JA, Langenbach GE, Kitayama T, Watanabe M, Sano R, Tanne K, Tanaka E : Changes in activity and structure of jaw muscles in Parkinson’s Disease model rats

J Oral Rehabil 40, 205-218, 2013.


Bai Y, Tsunematsu T, Jiao Q, Ohnuki Y, Mototani Y, Shiozawa K, Jin M, Cai W, Jin HL, Fujita T, Ichikawa Y, Suita K, Kurotani R, Yokoyama U, Sato M, Iwatsubo K, Ishikawa Y, Okumura S* : Pharmacological stimulation of type 5 adenylyl cyclase stabilizes heart rate under both microgravity and hypergravity induced by parabolic flight

J Pharamacological Sci 119, 381-389, 2012